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Liver thymidine kinase activity after cadmium-induced hepatotoxicity in rats
S E Theocharis1, A P Margeli, I K Ghiconti
1Department of Experimental Pharmacology, Medical School of Athens University, Greece.
Toxicology Letters
|November 1, 1992
Abstract:
Intraperitoneal (i.p.) administration of a cadmium (Cd) salt at concentrations of 1.0, 2.5 and 4.0 mg CdCl2/kg body wt. caused severe liver injury in rats 24 h after administration. The toxic effects were most evident in the intermediate dose of 2.5 mg. Thymidine kinase (TK), the key enzyme of the salvage pathway of DNA biosynthesis, was affected in all Cd-treated groups. TK activity presented lower values at the highest Cd-induced hepatotoxicity.
