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Signal transduction through the T-cell antigen receptor
R T Abraham1, L M Karnitz, J P Secrist
1Department of Immunology, Mayo Clinic, Rochester, MN 55905.
Trends in Biochemical Sciences
|October 1, 1992
Abstract:
The mechanism by which ligand binding to the T-cell antigen receptor triggers the T-cell activation program has long been one of the most fascinating questions in lymphocyte biology. Here, we review recent insights into the transmembrane signaling functions of this multisubunit receptor complex.