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Updated: Aug 11, 2026

Protein Misfolding Cyclic Amplification of Prions
Published on: November 7, 2012
Spongiform encephalopathy in a captive puma (Felis concolor)
K Willoughby1, D F Kelly, D G Lyon
1Department of Veterinary Clinical Science, University of Liverpool.
Abstract:
A captive adult puma developed ataxia, a hypermetric gait and whole body tremor. The signs progressed over a period of six weeks. Histopathological examination following euthanasia demonstrated spongiform encephalopathy, gliosis and mild non-suppurative meningoencephalitis. Immunostaining with a polyclonal antiserum revealed prion protein (PrP) associated with these changes in sections of cervical spinal cord and medulla. This is the first confirmed case of a scrapie-like spongiform encephalopathy described in a non-domestic cat in the United Kingdom.
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