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Related Experiment Videos

Language fMRI abnormalities associated with FOXP2 gene mutation.

Frédérique Liégeois1, Torsten Baldeweg, Alan Connelly

  • 1Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK. F.Liegeois@ich.ucl.ac.uk

Nature Neuroscience
|October 14, 2003
PubMed
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A mutation in the FOXP2 gene causes speech and language disorders in half of the KE family. Affected members show distinct brain activation patterns, suggesting FOXP2

Area of Science:

  • Neuroscience
  • Genetics
  • Linguistics

Background:

  • Half of the KE family exhibits a speech and language disorder linked to a FOXP2 gene mutation.
  • Previous studies noted bilateral morphological brain abnormalities in affected individuals.

Purpose of the Study:

  • To investigate functional brain abnormalities in individuals with a FOXP2 gene mutation.
  • To compare brain activation patterns during language tasks between affected and unaffected family members.

Main Methods:

  • Utilized functional magnetic resonance imaging (fMRI) during two language tasks: covert verb generation and overt verb generation/word repetition.
  • Analyzed brain activation patterns in affected and unaffected KE family members.

Main Results:

Related Experiment Videos

  • Unaffected members displayed typical left-dominant activation in Broca's area (generation) and bilateral activation (repetition).
  • Affected members showed more posterior and bilateral activation across all tasks.
  • Significant underactivation was observed in affected members in Broca's area, its right homolog, other language regions, and the putamen.

Conclusions:

  • The FOXP2 gene plays a critical role in the development of neural systems for speech and language.
  • FOXP2 mutations are associated with altered functional brain organization underlying language processing.