Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia

G Christopher Wood¹, Scott D Hanes, Bradley A Boucher

¹Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, 26 South Dunlap, Memphis, Tennessee 38163, USA. cwood@utmem.edu

|October 14, 2003

Abstract

Objective:

To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).

Design:

Observational case series.

Setting:

. The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.

Patients And Participants:

Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.

Interventions:

Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.

Measurements And Results:

Doxycycline or minocycline was successful in six of seven patients.

Conclusions:

Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.

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Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia

Objective:

Design:

Setting:

Patients And Participants:

Interventions:

Measurements And Results:

Conclusions:

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