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Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Immunization with Haemophilus influenzae (Hib) conjugate vaccine following discharge from hospital

B Olowokure1, N J Spencer, J I Hawker

  • 1Public Health Laboratory Service Communicable Disease Surveillance Centre, 2nd Floor Lincoln House, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK. bolowokure@cdscwmid.demon.co.uk

Infection
|October 14, 2003
PubMed

Insights

Many children with invasive Haemophilus influenzae type b (Hib) disease were not vaccinated before hospital admission. Delayed Hib conjugate vaccination after discharge significantly reduces individual and community protection.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health

Background:

  • Assessing Haemophilus influenzae type b (Hib) conjugate vaccine status post-hospitalization is crucial.
  • Understanding vaccination timeliness in unvaccinated children after discharge is essential for disease prevention.

Purpose of the Study:

  • To determine Hib conjugate vaccination status of children after hospital discharge.
  • To evaluate the time lag for Hib conjugate vaccination in unvaccinated children post-discharge.

Main Methods:

  • A population-based cross-sectional survey was conducted.
  • Participants included children aged 3-59 months with laboratory-confirmed invasive H. influenzae disease.

Main Results:

  • 82% of eligible children had not received the Hib conjugate vaccine before admission.
  • No children received the vaccine before hospital discharge.
  • Vaccination post-discharge averaged 110 days, with 28% remaining unvaccinated.

Conclusions:

  • Delayed Hib conjugate vaccination post-discharge was observed in the early post-vaccine era.
  • This delay diminishes the protective benefits of vaccination for both individuals and the community.
Abstract

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