Subchronic toxicity studies of fenbendazole in rats
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1Laboratory of Pharmacology and Toxicology, National Control Institute of Veterinary Bioproducts and Pharmaceuticals, Beijing, China.
Veterinary and Human Toxicology
|October 1, 1992
Abstract:
The effects of prolonged exposure of rats to fenbendazole were investigated. Fenbendazole was given daily by gavage for 14 consecutive days. These dosages (3000, 500 or 50 mg/kg/d) produced reductions in body weight gains. Renal tubular hyperemia or hemorrhage and glomerular capsule dilation, increased serum creatinine and hepatocellular granular degeneration occurred at dosages of 500 and 3000 mg/kg/d. Renal tubular epithelial cell granular degeneration and tubular dilation, increased serum glutamic pyruvic transaminase, cardiac hemorrhage and granular degeneration also occurred at 3000 mg/kg/d.