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Related Experiment Videos

Simazine toxicosis in sheep.

W J Allender1, J W Glastonbury

  • 1Chemistry Branch, Biological and Chemical Research Institute, New South Wales, Australia.

Veterinary and Human Toxicology
|October 1, 1992
PubMed
Summary

Simazine toxicosis in sheep causes severe tremors, tetany, and hind leg collapse. This herbicide poisoning leads to myocardial and hepatic damage, with significant simazine levels in affected livers.

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Area of Science:

  • Veterinary Toxicology
  • Sheep Health
  • Agricultural Chemical Safety

Background:

  • Investigated a case of simazine toxicosis in sheep.
  • Simazine is a widely used herbicide.
  • Understanding its toxic effects in livestock is crucial.

Observation:

  • Affected sheep displayed generalized muscle tremors, progressing to tetany and hind leg collapse.
  • Clinical signs included a distinctive prancing gait with the head tucked.
  • Mortality occurred within 2-3 days of symptom onset.

Findings:

  • Histopathology revealed mild to acute myocardial degeneration.
  • Livers showed mild to acute hepatic fatty change.
  • Simazine levels in livers ranged from <0.2 mg/kg to nearly 2 mg/kg in severely affected animals.

Implications:

  • This case highlights the severe neurological and organ damage simazine can cause in sheep.
  • Quantification of simazine in tissues is vital for diagnosing poisoning.
  • Highlights the need for careful herbicide management in agricultural settings to prevent livestock poisoning.

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