Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Phytoestrogens].

A Zittermann1

  • 1Institut für Ernährungswissenschaft, Universität Bonn. a.zittermann@uni-bonn.de

Zentralblatt Fur Gynakologie
|October 14, 2003
PubMed
Summary
This summary is machine-generated.

Phytoestrogens like soy isoflavones show no effect on menopausal symptoms or breast cancer risk factors. However, they may help prevent postmenopausal bone loss and lower cholesterol levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determinants of circulating calcitriol in cardiovascular disease.

The Journal of steroid biochemistry and molecular biology·2024
Same author

An Intervention Trial for Strengthening Medical Adherence after Heart Transplantation.

Progress in transplantation (Aliso Viejo, Calif.)·2022
Same author

Vitamin D supplementation of 4000 IU daily and cardiac function in patients with advanced heart failure: The EVITA trial.

International journal of cardiology·2019
Same author

Vitamin D supplementation and bone turnover in advanced heart failure: the EVITA trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017
Same author

Randomized supplementation of 4000 IU vitamin D<sub>3</sub> daily vs placebo on the prevalence of anemia in advanced heart failure: the EVITA trial.

Nutrition journal·2017
Same author

Adherence of Heart Transplant Recipients to Prescribed Medication and Recommended Lifestyle Habits.

Progress in transplantation (Aliso Viejo, Calif.)·2017
Same journal

About 150 births naturally after previous Caesarean section.

Zentralblatt fur Gynakologie·2010
Same journal

About lutein cysts found in hydrops foetus et placentae.

Zentralblatt fur Gynakologie·2010
Same journal

The potencies of the burner epithelium, especially a tendency to form serous epitrel, squamous and mucosal epithelium.

Zentralblatt fur Gynakologie·2010
Same journal

Two double birth defects causing obstetric difficulties.

Zentralblatt fur Gynakologie·2010
Same journal

The uterine size and fundus level in the first part of pregnancy.

Zentralblatt fur Gynakologie·2010
Same journal

The crossbar interposition.

Zentralblatt fur Gynakologie·2010
See all related articles

Area of Science:

  • Nutritional Science
  • Endocrinology
  • Preventive Medicine

Background:

  • Phytoestrogens, including soy isoflavones (genistein, daidzein) and flaxseed lignans (secoisolariciresinol, matairesinol), are plant compounds with estrogen-like activity.
  • Epidemiological studies suggest phytoestrogens may prevent estrogen-related diseases like breast cancer, menopausal symptoms, cardiovascular disease, and osteoporosis.

Purpose of the Study:

  • To critically review controlled clinical trials evaluating the effects of phytoestrogens on estrogen-related diseases and symptoms.
  • To assess the scientific evidence for phytoestrogen efficacy in preventing specific health conditions.

Main Methods:

  • Systematic review and critical appraisal of available controlled clinical trials on phytoestrogens.
  • Focus on studies investigating soy isoflavones due to extensive research.

Related Experiment Videos

Main Results:

  • No scientific evidence supports phytoestrogens' effect on menopausal symptoms or breast cancer risk factors.
  • Soy protein containing isoflavones demonstrated a reduction in total cholesterol, LDL cholesterol, and triglyceride serum levels.
  • Strongest evidence indicates soy isoflavones help prevent postmenopausal bone loss in the lumbar spine.

Conclusions:

  • Phytoestrogens do not appear to significantly impact menopausal symptoms or breast cancer risk based on current clinical trial data.
  • Soy isoflavones show potential benefits for cardiovascular health markers (cholesterol, triglycerides) and bone health in postmenopausal women.
  • Differential effects on estrogen-related diseases may be linked to isoflavone affinity for estrogen receptors alpha and beta and their tissue distribution.