Related Experiment Video
Updated: Aug 30, 2026

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
Published on: August 16, 2020
[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease]
Jing-jing Su1, Hui-jun Xie, Wu-wei Zhao
1Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 P R China. jjsulcg@yahoo.com
Objective:
To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.
Methods:
Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.
Results:
The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.
Conclusion:
These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Neural Regulation
Parkinson's Disease: Overview

