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Related Experiment Videos

Local commissural interneurons integrate information from intersegmental coordinating interneurons.

Brian Mulloney1, Wendy M Hall

  • 1Section of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616-8519, USA. bcmulloney@ucdavis.edu

The Journal of Comparative Neurology
|October 14, 2003
PubMed
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Coordinating axons in crayfish ganglia were mapped, revealing connections with local interneurons (ComInt 1) that control swimmeret movements. These findings clarify neural circuits for rhythmic abdominal behaviors.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Crustacean Neurobiology

Background:

  • Interneurons coordinate swimmeret movements in crayfish by projecting axons between abdominal ganglia.
  • The precise anatomical pathways and synaptic targets of these coordinating axons within target ganglia were not fully understood.

Purpose of the Study:

  • To elucidate the anatomical organization of coordinating interneuron axons within target abdominal ganglia in crayfish.
  • To identify the synaptic connections and functional roles of local interneurons involved in swimmeret coordination.

Main Methods:

  • Neurobiotin and dextran-Texas Red microelectrodes were used to fill coordinating axons near their targets in crayfish abdominal ganglia.
  • Axonal trajectories, branching patterns, and synaptic connections with local interneurons were analyzed using microscopy.

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Main Results:

  • Coordinating axons were found to run near the midline in target ganglia with limited branching.
  • Two of three axon types synapsed directly onto local commissural interneurons (ComInt 1 neurons).
  • ComInt 1 neurons are nonspiking, receive input via EPSPs, use graded transmission, and differentially modulate motor neuron activity for swimmeret strokes.

Conclusions:

  • ComInt 1 neurons are key relays for intersegmental coordination of swimmeret movements.
  • The findings provide insights into the neural circuitry underlying rhythmic motor pattern generation and intersegmental coordination in crayfish.