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[Platelets and arterial thrombosis]

Jean-Pierre Cazenave1, Christian Gachet, François Lanza

  • 1Etablissement Français du Sang-Alsace, INSERM U.311, BP 36, 10 rue Spielmann-67065 Strasbourg.

Bulletin De L'Academie Nationale De Medecine
|October 15, 2003
PubMed

The pathological mechanisms involved in arterial thrombus formation are similar to the mechanisms involved in physiological hemostasis. Arterial thrombosis is initiated following lesion of the vessel wall, either through rupture of an atherosclerotic plaque containing lipids, adhesive proteins and tissue factor or after angioplasty exposing the thrombogenic subendothelial matrix. Platelets play a major role in arterial thrombus formation through ADP secretion and thrombin generation on their activated surface. Arterial thrombosis is a frequent complication of atherosclerotic lesions and leads to acute ischemic events. These events are therapeutic emergencies which require administration of antithrombotic drugs inhibiting platelet functions and thrombin.

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