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Related Experiment Videos

Negative pressure breathing enhances nitrogen elimination.

Timothy B Curry1, Claes E Lundgren

  • 1Center for Research and Education in Special Environments, Department of Physiology and Biophysics, University at Buffalo, Buffalo, NY 14222, USA.

Aviation, Space, and Environmental Medicine
|October 15, 2003
PubMed
Summary

Negative pressure breathing (NPB) enhances nitrogen elimination by 39%, aiding in decompression scenarios. This method may improve inert gas washout, potentially benefiting divers and those treated for decompression sickness.

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Area of Science:

  • Physiology
  • Diving Medicine
  • Respiratory Physiology

Background:

  • Nitrogen elimination during decompression relies on tissue perfusion and cardiac output (CO).
  • Negative pressure breathing (NPB) is hypothesized to boost CO by improving venous return, thus accelerating nitrogen elimination.

Purpose of the Study:

  • To investigate the effect of NPB on nitrogen elimination rates.
  • To determine if NPB influences cardiac output and blood flow distribution.

Main Methods:

  • Nitrogen elimination was measured in five supine subjects over 2 hours.
  • Subjects breathed a nitrogen-free gas mixture at either -15 cm H2O (NPB) or atmospheric pressure.

Main Results:

  • NPB increased nitrogen elimination by 39.2% and calf blood flow by 34.1%.

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  • Cardiac output did not significantly change with NPB.
  • A slight increase in blood pressure was observed during NPB.

    • Conclusions:

    • NPB effectively increases nitrogen elimination, potentially through blood flow redistribution rather than increased CO.
    • NPB is a promising method for enhancing inert gas washout in decompression and treating decompression sickness.