Related Experiment Video
Updated: Aug 30, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Contraindicated antiretroviral drug combinations
Abe Macher1, David Thomas, Sindy M Paul
1Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Public Health Service, Rockville, Maryland, USA.
Abstract:
The proper implementation of combination antiretroviral treatment regimens is fundamental to successful therapeutic outcomes for patients with HIV/AIDS. Unfortunately, some patients are still being prescribed contraindicated antiretroviral regimens that include: 1. stavudine plus zidovudine; 2. Invirase plus two nucleoside analog reverse transcriptase inhibitors (NRTIS); 3. zalcitabine plus didanosine; 4. zalcitabine plus stavudine; and, 5. zalcitabine plus lamivudine. Inappropriate regimens such as these either have limited effectiveness or potential severe toxicity.
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