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Related Experiment Videos

Coliform mastitis.

Joe Hogan1, K Larry Smith

  • 1Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, 44691, USA. hogan.4@osu.edu

Veterinary Research
|October 15, 2003
PubMed
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Coliform mastitis in cows is caused by Gram-negative bacteria from the environment. Core-antigen bacterins can reduce the severity and duration of this bovine mastitis.

Area of Science:

  • Veterinary Microbiology
  • Animal Science
  • Bovine Health

Background:

  • Gram-negative bacteria, particularly coliforms, are significant environmental pathogens causing bovine mastitis.
  • Infection sources include bedding, soil, and manure, with prevalence increasing during favorable environmental conditions.
  • The teat canal serves as the entry point into the mammary gland.

Purpose of the Study:

  • To investigate the factors influencing coliform mastitis in dairy cows.
  • To understand bacterial adaptation and host defense mechanisms during infection.
  • To evaluate the efficacy of core-antigen bacterins in managing coliform mastitis.

Main Methods:

  • Characterization of environmental sources of Gram-negative bacteria.
  • Analysis of bacterial replication and host evasion strategies within the mammary gland.

Related Experiment Videos

  • Assessment of host immune responses, including neutrophil migration and endotoxin effects.
  • Evaluation of core-antigen bacterins in mitigating clinical signs.

    • Main Results:

    • Coliform mastitis rates are higher during periods of increased environmental bacterial populations and during the non-lactating phase.
    • Bacterial iron acquisition from mammary secretions is crucial for infecting the non-lactating gland.
    • Neutrophil activity and endotoxin release are key components of the host response during lactation.
    • Core-antigen bacterins demonstrated a reduction in clinical sign severity and duration.

    Conclusions:

    • Environmental management and understanding bacterial virulence factors are critical for controlling coliform mastitis.
    • Host defenses, including neutrophil activity, play a vital role during lactation.
    • Core-antigen bacterins offer a promising strategy for reducing the impact of coliform mastitis in dairy cattle.