Related Experiment Video

Updated: Aug 30, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Aneuploidy screening of preimplantation embryos using comparative genomic hybridization versus fluorescence in situ

David L Hill1

  • 1ART Reproductive Center, Beverly Hills, California 90210, USA. embryonics@adelphia.net

Fertility and Sterility
|October 15, 2003
PubMed
Abstract

No abstract available in PubMed .

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...