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Updated: Aug 30, 2026

The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization
Published on: October 18, 2024
Pregnancy outcomes using donor sperm insemination after failed in vitro fertilization with intracytoplasmic sperm
Marsha J Gorrill1, Kenneth A Burry, Phillip E Patton
1Oregon Health and Science University, Portland, Oregon, USA. gorrillm@ohsu.edu
Objective:
To evaluate alternatives for couples with severe male factor infertility who fail to conceive with IVF-intracytoplasmic sperm injection (ICSI).
Design:
Outcomes of couples using artificial insemination with donor sperm (AID) after failed IVF-ICSI, assessing multiple risk factors affecting prognosis.
Setting:
University infertility service.
Patient(S):
Nineteen patients with complex infertility disorders who failed IVF-ICSI and subsequently used AID (1 to 7 cycles).
Intervention(S):
Artificial insemination with donor sperm was performed 36 hours after detection of an LH surge or hCG injection.
Main Outcome Measure(S):
Pregnancy outcomes were determined.
Result(S):
Seventeen pregnancies occurred in 16 women associated with AID for a pregnancy rate per cycle of 27.9% within a mean of 3.2 +/- 18 cycles. Live birth rate per cycle was 24.6%.
Conclusion(S):
A high pregnancy rate was achieved with AID in women who failed IVF-ICSI. Given the low cost and effectiveness of AID in this series, consideration of AID is a reasonable and effective option even in couples with poor prognosis who fail to conceive with IVF-ICSI.
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