Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

'Complementing' viral infection: mechanisms for evading innate immunity.

Sun-Hwa Lee1, Jae U Jung, Robert E Means

  • 1Division of Tumor Virology, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772, USA.

Trends in Microbiology
|October 15, 2003
PubMed
Summary

Viruses evolve sophisticated strategies to evade host immunity, including neutralizing complement. This review explores viral complement evasion and exploitation mechanisms for immune system advantage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HIV-1 protease cleavage sites detection with a quantum convolutional neural network algorithm.

Scientific reports·2026
Same author

IL-27-mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection.

Science translational medicine·2026
Same author

Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Immunopathogenic insights into members of the class Bunyaviricetes: a comparative review of emerging zoonotic threats.

Current opinion in virology·2026
Same author

Maternal-infant immune signatures in infants at risk for SARS-CoV-2-associated neurodevelopmental disorders.

Communications biology·2026
Same author

Performance evaluation of quantum support vector machine for COVID-19 biomarker analysis.

Computer methods and programs in biomedicine·2026

Area of Science:

  • Virology
  • Immunology
  • Molecular Biology

Background:

  • Viruses co-evolve with hosts, developing diverse immune evasion mechanisms.
  • Many viruses target the host's complement system, a crucial innate immune defense.
  • Understanding viral strategies is key to combating viral infections.

Purpose of the Study:

  • To review viral strategies for evading and manipulating the host complement system.
  • To discuss the diversity of viral complement control proteins.
  • To explore how viruses utilize the immune system for their own benefit.

Main Methods:

  • Literature review of viral immune evasion mechanisms.
  • Analysis of viral protein functions related to complement regulation.
  • Discussion of proposed mechanisms of viral immune system exploitation.

Related Experiment Videos

Main Results:

  • Viruses employ varied mechanisms to neutralize complement activity.
  • Viral proteins directly interfere with complement cascade pathways.
  • Some viruses may harness complement components for replication or spread.

Conclusions:

  • Viral complement evasion is a complex and diverse evolutionary adaptation.
  • Viruses actively manipulate host immunity, not just avoid it.
  • Further research into these mechanisms could reveal novel therapeutic targets.