Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cell therapy for ischemic heart disease.

Rutger J Hassink1, Joshua D Dowell, Aart Brutel de la Rivière

  • 1University Medical Center, Heart Lung Center, Dept of Cardio-Thoracic Surgery, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. rutger@niob.knaw.nl

Trends in Molecular Medicine
|October 15, 2003
PubMed
Summary

Cell transplantation shows promise for heart disease treatment. Surprisingly, even non-cardiomyogenic cells can improve cardiac function, suggesting functional integration isn't essential for therapeutic benefits in ischemic heart disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specialist Awareness of IR: Current State of Affairs and Opportunities for Improvement.

Journal of vascular and interventional radiology : JVIR·2025
Same author

Musings on intrinsic cardiomyocyte cell cycle activity and myocardial regeneration.

Journal of molecular and cellular cardiology·2023
Same author

A History and Modern Framework for Quality Improvement in Interventional Radiology.

Journal of vascular and interventional radiology : JVIR·2023
Same author

Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.

Circulation·2022
Same author

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.

Science (New York, N.Y.)·2022
Same author

Hepatocellular carcinoma locoregional therapies: Outcomes and future horizons.

World journal of gastroenterology·2021

Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Cell transplantation is explored for heart disease therapy, initially assuming donor cardiomyocyte integration.
  • Recent findings reveal non-cardiomyogenic cells also improve cardiac function, challenging this assumption.
  • Adult stem cells may possess a broader developmental potential than previously thought.

Purpose of the Study:

  • To review current challenges and opportunities in stem cell transplantation for ischemic heart disease.
  • To discuss the therapeutic potential of cell transplantation beyond direct cardiomyocyte integration.
  • To explore the implications of adult stem cell plasticity for cardiac repair.

Main Methods:

  • Review of recent experimental and clinical observations.

Related Experiment Videos

  • Discussion of findings related to cell integration and cardiac function.
  • Analysis of adult stem cell developmental potential.

    • Main Results:

    • Transplanted cells, including non-cardiomyogenic types, can improve cardiac function.
    • Functional integration of donor cells may not be a prerequisite for therapeutic effects.
    • Adult stem cells exhibit significant, potentially underestimated, developmental plasticity.

    Conclusions:

    • Stem cell transplantation offers a promising therapeutic avenue for ischemic heart disease.
    • The mechanism of benefit may involve paracrine effects or other non-integrative processes.
    • Further research into adult stem cell capabilities could unlock new cardiac restoration strategies.