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Published on: January 20, 2023
Abusive head injury as a cause of apparent life-threatening events in infancy
Robin L Altman1, Donald A Brand, Scott Forman
1Department of Pediatrics, Westchester Medical Center, Valhalla, USA. robin_altman@nymc.edu
Insights
Abusive head injury is a frequent cause of apparent life-threatening events (ALTEs) in infants, necessitating its consideration in diagnosis. Early ophthalmologic evaluation and cranial imaging are recommended for infants with ALTEs.
Area of Science:
- Pediatrics
- Neonatology
- Child Abuse
Background:
- An apparent life-threatening event (ALTE) is characterized by infant breathing abnormalities, color changes, or altered muscle tone/mental status.
- Abusive head injuries were identified in infants admitted for ALTE evaluation.
Purpose of the Study:
- To systematically investigate the diverse causes of ALTEs in infants.
- To determine the relative frequencies of identified ALTE causes.
Main Methods:
- A prospective consecutive case series design was employed.
- 243 infants under 12 months with ALTEs were evaluated over 32 months at a tertiary care center.
Main Results:
- Thirty-five distinct causes of ALTEs were identified.
- Abusive head injuries accounted for 2.5% of cases (1 admission every 5 months).
- Two of three infant deaths were attributed to abusive head injuries.
Conclusions:
- ALTEs stem from a broad range of medical conditions.
- Abusive head injury is a significant and frequent cause of ALTEs, requiring inclusion in differential diagnoses.
- Ophthalmologic evaluation and cranial imaging are crucial early diagnostic steps for ALTEs when the cause is not immediately apparent.
Background:
An apparent life-threatening event (ALTE) refers to the sudden occurrence of a breathing abnormality, color change, or alteration in muscle tone or mental status in an infant. Several patients with ALTEs admitted to our institution were found to have sustained abusive head injuries.
Objective:
To systematically examine the possible causes of ALTEs and their relative frequencies.
Study Design:
Prospective consecutive case series of 243 infants younger than 12 months admitted to a tertiary care academic medical center for evaluation of an ALTE during a 32-month interval.
Results:
Thirty-five different causes of ALTEs were identified. Six subjects (2.5%) were diagnosed as having abusive head injuries, or 1 admission every 5 months. Three patients died in the hospital, 2 of whom were diagnosed as having abusive head injuries.
Conclusions:
A wide spectrum of diseases and disorders can precipitate an ALTE. Among them, abusive head injury, a recently recognized cause, occurs frequently enough to obligate its inclusion in the differential diagnosis. An ophthalmologic evaluation with dilated fundus examination and cranial imaging should therefore be considered early in the investigation unless another cause becomes apparent soon after admission.
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