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Updated: Jul 14, 2026

Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
Cardiac memory and cortical memory: do learning patterns in neural networks impact on cardiac arrhythmias?
Michael R Rosen1, Ofer Binah, Shimon Marom
1Department of Pharmacology, Center for Molecular Therapeutics, New York, NY, USA. mrr1@columbia.edu
Abstract:
Memory is a property of diverse biological systems, including brain and heart. Studies in cortical neuronal networks have identified an increased sensitivity to infrequent (rare) stimulation patterns that can result in their achieving dominance over network firing. This adaptive behavior is applied to the heart in an attempt to explain the ability of pulmonary venous and other ectopic foci to achieve dominance over cardiac rhythm. Developmental changes in determinants of cardiac rhythm are explored as possible determinants of the range of rhythms expressed by the heart. By understanding the mechanisms for these behavior patterns, we may obtain new means for manipulating memory to return dysrhythmic hearts to normal sinus rhythm.
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