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Octreotide abolishes the acute decrease in bone turnover in response to oral glucose.

Jackie A Clowes1, Heather C Allen, Donna M Prentis

  • 1Bone Metabolism Group, Clinical Sciences (North), University of Sheffield, Sheffield, United Kingdom S5 7AU. j.a.clowes@sheffield.ac.uk

The Journal of Clinical Endocrinology and Metabolism
|October 15, 2003
PubMed
Summary
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Oral glucose intake acutely suppresses bone turnover, but this effect is blocked by octreotide. This suggests gastrointestinal hormones mediate the feeding-induced bone response.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Gastrointestinal Physiology

Background:

  • Oral glucose intake acutely suppresses bone turnover.
  • Insulin does not appear to mediate this glucose-induced suppression.
  • Gastrointestinal hormones may play a role in modulating bone turnover.

Purpose of the Study:

  • To investigate if inhibiting gastrointestinal hormone production with octreotide can block glucose-mediated bone turnover suppression.
  • To identify potential endocrine factors involved in the bone response to feeding.

Main Methods:

  • A randomized, single-blind, crossover study involving 15 subjects.
  • Four study conditions: oral placebo/IV saline, oral glucose/IV saline, oral glucose/IV octreotide, and IV octreotide alone.
  • Measurement of bone turnover markers (serum/urinary CTX, osteocalcin, P1NP), PTH, insulin, calcium, and glucose over 4 hours.

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Main Results:

  • Oral glucose significantly decreased all measured bone turnover markers.
  • Octreotide infusion completely abolished the bone turnover suppression in response to oral glucose.
  • Octreotide alone significantly increased bone turnover markers and PTH levels.

Conclusions:

  • Octreotide completely blocks the bone turnover response to oral glucose intake.
  • The bone turnover response to feeding is likely mediated by an octreotide-inhibitable endocrine factor.
  • Gastrointestinal hormones are implicated in regulating bone metabolism post-glucose ingestion.