Related Experiment Video

Updated: Aug 30, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Dobutamine stress echocardiography in hypertrophic cardiomyopathy

Maria Angela Losi1, Sandro Betocchi, Mariano Aversa

  • 1Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Via Pansini 5, IT-80131 Naples, Italy. losi@unina.it

Cardiology
|October 15, 2003
PubMed

Insights

Dobutamine stress echocardiography (DSE) can induce new wall motion abnormalities (NWMA) in hypertrophic cardiomyopathy (HCM) patients, linked to reduced left ventricular (LV) function and potentially ischemia. The septum shows no contractile reserve during DSE in HCM.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Heart Diseases

Background:

  • Myocardial ischemia is common in hypertrophic cardiomyopathy (HCM) without coronary artery disease.
  • Dobutamine stress echocardiography (DSE) can provoke new wall motion abnormalities (NWMA) in some HCM patients.

Purpose of the Study:

  • To assess the impact of dobutamine on left ventricular (LV) performance and hemodynamics in patients with HCM.
  • To investigate the characteristics of NWMA induced by DSE in HCM.

Main Methods:

  • Eighteen patients with non-obstructive HCM underwent DSE with incremental dobutamine doses.
  • Hemodynamic parameters, LV dimensions, and wall motion were assessed during stress.
  • Patients were categorized based on the development of NWMA.

Main Results:

  • Seven patients developed NWMA; 11 did not.
  • NWMA patients showed a greater heart rate increase and a decrease in LV ejection fraction and fractional shortening.
  • LV outflow tract gradient increased similarly in both groups; posterior wall thickened, but septal thickening did not increase.

Conclusions:

  • DSE can induce NWMA in a subset of HCM patients, associated with increased heart rate and depressed global LV systolic performance.
  • NWMA in HCM may be related to ischemia or impaired LV function due to rapid heart rates.
  • The interventricular septum exhibits no contractile reserve during DSE in HCM, irrespective of NWMA.
Abstract

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...