Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating nicotine dependence.

Elbert D Glover1, Penny N Glover, Thomas J Payne

  • 1Deparment of Behavioral Medicine & Psychiatry, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506-9135, USA. eglover@hsc.wvu.edu

The American Journal of the Medical Sciences
|October 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles.

Nature nanotechnology·2025
Same author

Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting.

Molecular therapy. Methods & clinical development·2024
Same author

Initial experimentation with tobacco is associated with subsequent tobacco use patterns among youth in the United States.

PloS one·2024
Same author

Tailored Monoacyl Poly(2-oxazoline)- and Poly(2-oxazine)-Lipids as PEG-Lipid Alternatives for Stabilization and Delivery of mRNA-Lipid Nanoparticles.

Biomacromolecules·2024
Same author

CRISPR-Cas13b-mediated suppression of HBV replication and protein expression.

Journal of hepatology·2024
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Nicotine addiction involves brain dopamine changes, leading to dependence. Effective treatments include nicotine replacement therapy and bupropion SR, especially when combined with behavioral counseling for best outcomes.

Area of Science:

  • Neuroscience
  • Addiction Medicine
  • Pharmacology

Background:

  • Nicotine addiction is a significant public health issue.
  • Nicotine's psychoactive effects are mediated by dopamine pathways in the brain.
  • Understanding the biological basis of nicotine dependence is crucial for developing effective treatments.

Purpose of the Study:

  • To review the biological mechanisms underlying nicotine addiction.
  • To identify and evaluate the most effective pharmacological and behavioral treatments for nicotine dependence.

Main Methods:

  • Literature review of biological and clinical studies on nicotine addiction.
  • Analysis of neurobiological data on dopamine's role in nicotine reinforcement.
  • Synthesis of evidence on the efficacy of various treatment modalities.

Related Experiment Videos

Main Results:

  • Nicotine elevates brain dopamine levels, reinforcing drug-seeking behavior and leading to dependence.
  • Nicotine replacement therapy (NRT) and bupropion SR are identified as the most effective pharmacological adjuncts.
  • Combined pharmacological treatment with behavioral counseling yields the best patient outcomes.

Conclusions:

  • Nicotine dependence is a complex neurobiological condition.
  • Pharmacological treatments like NRT and bupropion SR are key components in managing nicotine addiction.
  • Integrated treatment approaches combining medication and behavioral support are essential for successful nicotine cessation.