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Updated: Aug 30, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Morbilliform drug reaction with histologic features of pustular dermatosis associated with bryostatin-1
Jennifer M Krejci-Manwaring1, Melissa A Bogle, Hafeez A Diwan
1Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Abstract:
Bryostatin-1 is a new chemotherapeutic agent that inhibits protein kinase C. The most common side effect and the dose limiting toxicity is myalgia. The cutaneous side effects reported during the phase I and II trials were alopecia, mucositis, nonspecific "rash," "bronzing," and hyperpigmentation in sun exposed areas. No specific acute drug eruptions have been reported. We present the first reported case of a morbilliform drug eruption with histologic features of intraepidermal and subcorneal spongiotic pustules containing eosinophils secondary to bryostatin-1.
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