Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maternal-conceptus cross talk--a review.

P Viganò1, S Mangioni, F Pompei

  • 1II Department of Obstetrics and Gynecology, University of Milano, 20122 Milano, Italy. paola.vigano@unimi.it

Placenta
|October 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduced live birth rates following ART in adenomyosis patients: a matched control study.

Human reproduction (Oxford, England)·2025
Same author

Untreated ovarian endometrioma: not just a matter of dimensional change over time.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

'Guess who'? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations.

European journal of obstetrics, gynecology, and reproductive biology·2022
Same author

Greater estimated fetal weight and birth weight in IVF/ICSI pregnancy after frozen-thawed vs fresh blastocyst transfer: prospective cohort study with novel unified modeling methodology.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021
Same author

Impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study.

Archives of gynecology and obstetrics·2021
Same author

Is a freeze-all policy the optimal solution to circumvent the effect of late follicular elevated progesterone? A multicentric matched-control retrospective study analysing cumulative live birth rate in 942 non-elective freeze-all cycles.

Human reproduction (Oxford, England)·2021

Successful pregnancy relies on conceptus-endometrium communication. Understanding this molecular dialogue, involving various factors like chemokines and vitamin D, is key for reproductive health advancements.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Immunology

Background:

  • Successful pregnancy requires a functional conceptus, receptive endometrium, and communication between them.
  • This communication involves a complex network of paracrine factors, including gonadal steroids, chemokines, cytokines, adhesion molecules, and growth factors.
  • Emerging evidence suggests the soluble form of HLA-G and the vitamin D system also play roles in this crucial cross-talk.

Purpose of the Study:

  • To explore the molecular mechanisms underlying the communication between the conceptus and endometrium during implantation.
  • To highlight the diverse biological molecules involved in this paracrine dialogue.
  • To underscore the potential for developing novel therapeutic and diagnostic agents based on a deeper understanding of these processes.

Related Experiment Videos

Main Methods:

  • Review and synthesis of existing literature on implantation and placentation.
  • Analysis of the roles of various signaling molecules, including chemokines, cytokines, adhesion molecules, growth factors, soluble HLA-G, and vitamin D.
  • Discussion of the pleiotropic and redundant nature of these factors.

Main Results:

  • Implantation and placentation are critically dependent on a sophisticated paracrine dialogue between the conceptus and endometrium.
  • This dialogue involves a wide array of molecules, often exhibiting redundant and pleiotropic effects.
  • The soluble form of HLA-G and the vitamin D system are identified as recent additions to the known factors facilitating this communication.

Conclusions:

  • A comprehensive understanding of the molecular mechanisms governing conceptus-endometrium communication is essential for reproductive health.
  • Further research into these pathways can lead to the development of new agents for regulating reproductive function.
  • These advancements hold potential for novel diagnostic, biological, and therapeutic applications in fertility and pregnancy management.