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Relationship between myocardial viability and the predischarge electrocardiographic pattern in patients with first
Ramazan Atak1, Hasan Turhan, Kubilay Senen
1Turkiye Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey. hratak@yahoo.com
Insights
Isoelectric ST segments and negative T waves on ECG strongly suggest viable myocardium after acute myocardial infarction (AMI). However, their absence does not rule out myocardial viability, requiring further assessment.
Area of Science:
- Cardiology
- Medical Imaging
- Electrocardiography
Background:
- Assessing residual myocardial viability post-acute myocardial infarction (AMI) is crucial for patient prognosis and treatment.
- Electrocardiographic (ECG) patterns of ST segment and T wave abnormalities are commonly observed after AMI.
Purpose of the Study:
- To determine the correlation between myocardial viability, assessed by low-dose dobutamine stress echocardiography (LDDSE), and specific ECG patterns.
- To evaluate the predictive value of ST segment and T wave morphology for myocardial viability in patients with anterior AMI.
Main Methods:
- Sixty-nine patients with first-episode transmural AMI underwent LDDSE at the end of the first week.
- Patients were categorized into four groups based on ST segment (elevation or isoelectric) and T wave (positive or negative) morphology.
- Two-dimensional echocardiography was performed at rest and during LDDSE.
Main Results:
- Myocardial viability was significantly more frequent in patients with isoelectric ST segments (92%) compared to those with elevated ST segments (47%).
- Negative T waves were associated with higher rates of myocardial viability (71%) than positive T waves (46%).
- Isoelectric ST segments showed high specificity (92%) but moderate sensitivity (51%) for viable myocardium.
Conclusions:
- Isoelectric ST segments and negative T waves on ECG are strong indicators of myocardial viability after AMI.
- The absence of these specific ECG patterns does not exclude the presence of viable myocardium, necessitating further investigation.
Background:
The assessment of residual viability in the infarcted area after an acute myocardial infarction is relevant to subsequent management and prognosis.
Objective:
The aim of this study was to investigate the correlation between myocardial viability after an acute anterior myocardial infarction (AMI) as assessed by low dose dobutamine stress echocardiography (LDDSE) and the electrocardiographic patterns of ST segment and T wave abnormalities at the end of the first week of the acute event.
Methods:
Sixty-nine consecutive patients (51 men, 18 women, mean age+/-standard deviation=57+/-11 years) who admitted to our clinic due to a first episode of transmural AMI were included in this study. Two-dimensional echocardiography was performed to all patients during rest and low dose dobutamine administration at the end of the first week of admission (7+/-2 days). Patients were classified into four groups according to ST segment and T wave morphology: group A, ST elevation < or =0.1 mV and negative T waves; group B, ST elevation < or =0.1 mV and positive T waves; group C, ST elevation > or =0.1 mV and negative T waves and group D, ST elevation > or =0.1 mV and positive T waves.
Results:
Myocardial viability was detected more often in patients with isoelectric ST segments (22/24, 92%) than those with elevated ST segments (21/45, 47%) (P<0.001). Similarly patients with negative T waves had myocardial viability more frequently compared to those with positive T waves (32/45, 71% vs. 11/24, 46%, P<0.01). Seventeen (94%) of 18 patients in group A and 5 (83%) of six patients in group B had viable myocardium (P>0.05). Myocardial viability was found in 15 (56%) of 27 patients in group C and six (33%) of 18 patients in group D (P<0.01). As a marker of viable myocardium, isoelectricity of ST segment was specific (92%) but only moderately sensitive (51%), with a 92% positive predictive accuracy and a poor (53%) negative predictive value. T wave negativity was less specific but more sensitive than isoelectricity of ST segment for myocardial viability.
Conclusion:
The presence of isoelectric ST segment and negative T wave indicates a high probability of myocardial viability. However, absence of these electrocardiographic patterns does not exclude the presence of viable myocardium.
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