Related Experiment Video
Updated: Aug 30, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine
Tomoji Mashimo1, Philippe Glaser, Marianne Lucas
1Unité de Génétique des Mammifères, Institut Pasteur, 75724 Paris Cedex 15, France.
Abstract:
2',5'-Oligoadenylate synthetases (2',5'-OASs) are interferon-inducible enzymes. Some of these proteins play an important role in cellular physiology, in particular, in the innate defense mechanisms against RNA virus infections. In the present publication we report the complete genomic structure of the cluster of genes encoding mouse 2',5'-OAS, with all its transcription units, their predicted functions, and their evolutionary relationships. We found that mouse Oas2/Oas3 genes have a genomic structure similar to that of human OAS2/OAS3, while the mouse equivalent of human OAS1 is composed of eight (Oas1a to Oas1h) tandemly arranged transcription units. For all these eight genes a specific inducible promoter controls transcription. The possible functions of this family of proteins are discussed.
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Modern Molecular Taxonomy
Cis-regulatory Sequences
Cis-regulatory Sequences
Ligand Binding and Linkage
Prokaryotic Gene Structure and Organization

