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Related Experiment Video

Updated: May 11, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Unique lipoprotein phenotype and genotype associated with exceptional longevity.

Nir Barzilai¹, Gil Atzmon, Clyde Schechter

¹Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA. barzilai@aecom.yu.edu

|October 16, 2003

Summary

Exceptional longevity is linked to larger high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particle sizes. This heritable trait, associated with a specific gene variant, promotes healthy aging and reduces disease risk.

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Area of Science:

Genetics
Gerontology
Cardiovascular Science

Background:

Exceptional longevity is associated with delayed onset of age-related diseases.
Family members of long-lived individuals may inherit factors influencing aging and disease susceptibility.

Purpose of the Study:

Identify biological and genetic factors defining a human longevity phenotype.
Investigate the role of lipoprotein particle size and CETP gene variation in longevity.

Main Methods:

Case-control study of Ashkenazi Jewish probands with exceptional longevity and their offspring, compared to age-matched controls.
Analysis of lipid and lipoprotein subclass particle sizes using proton nuclear magnetic resonance.
Genotyping for the cholesteryl ester transfer protein (CETP) I405V gene variation.

Main Results:

Probands and their offspring exhibited significantly larger HDL and LDL particle sizes compared to controls.
Larger lipoprotein particle sizes were associated with lower prevalence of hypertension, cardiovascular disease, and metabolic syndrome.
Increased frequency of homozygosity for the CETP 405 valine allele (VV genotype) was observed in probands and offspring.

Conclusions:

Larger HDL and LDL particle sizes are a heritable phenotype associated with exceptional longevity.
This lipoprotein phenotype correlates with reduced risk of age-related diseases.
The CETP I405V variant may play a role in promoting a healthy aging phenotype.