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Presacral multiple cellular schwannomas.

Akira Ogose1, Tetsuo Hotta, Hiroshi Hatano

  • 1Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. aogose@med.niigata-u.ac.jp

Spine
|October 16, 2003
PubMed
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Multiple cellular schwannomas, a rare variant of benign schwannoma, can occur even without neurofibromatosis. This case report highlights their potential for recurrence and emphasizes diagnostic markers.

Area of Science:

  • Oncology
  • Neurosurgery
  • Pathology

Background:

  • Cellular schwannoma, a variant of benign schwannoma, is often misdiagnosed as sarcoma.
  • Typically presents as a solitary lesion, making multiple occurrences rare.

Observation:

  • A case report details a 39-year-old woman with multiple presacral tumors along the sacral nerve root.
  • The patient had no clinical stigmata of neurofibromatosis.
  • Tumors recurred multiply 19 years post-initial resection.

Findings:

  • Thirteen tumors were resected using both anterior and posterior surgical approaches.
  • Immunohistochemical analysis using S-100 protein and Ki-67 aided in differentiating cellular schwannoma from malignant peripheral nerve sheath tumors.

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Implications:

  • This case demonstrates that multiple cellular schwannomas can develop in patients without neurofibromatosis.
  • Highlights the importance of considering multiple schwannomas in the differential diagnosis of presacral tumors.
  • Suggests the need for long-term surveillance due to recurrence potential.