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Alkaloidal constituents from Aconitum jaluense
Sang Hee Shim1, Ju Sun Kim, Sam Sik Kang
1Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Archives of Pharmacal Research
|October 17, 2003
Summary
This study identified eight alkaloids from Aconitum jaluense Komar., including five novel compounds. Alkaloid profiles may differ between plant collections, impacting research.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Background:
- Aconitum jaluense Komar. is a plant species found in the Korean peninsula.
- Previous research on its alkaloidal constituents exists, but variations may occur.
Purpose of the Study:
- To investigate and isolate the alkaloidal constituents of Aconitum jaluense Komar.
- To identify known and potentially novel alkaloids within the plant species.
Main Methods:
- Isolation of alkaloids from Aconitum jaluense Komar. using phytochemical techniques.
- Structure elucidation of isolated compounds based on spectral data analysis.
Main Results:
- Eight alkaloids were isolated: seven C19-norditerpenoid and one C20-diterpenoid.
- Three known alkaloids (neoline, mesaconitine, hypaconitine) and five new alkaloids (lipomesaconitine, lipohypaconitine, 15alpha-hydroxyneoline, hokbusine A, napelline) were identified.
- Spectral data confirmed the structures of all isolated alkaloids.
Conclusions:
- The phytochemical investigation of Aconitum jaluense Komar. yielded a diverse range of alkaloids.
- Comparison with prior studies revealed differences in alkaloid content, highlighting the variability in natural products.