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Related Experiment Videos

mTOR signaling to translation.

A C Gingras1, B Raught, N Sonenberg

  • 1Department of Biochemistry, McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, H3G 1Y6, Canada.

Current Topics in Microbiology and Immunology
|October 17, 2003
PubMed
Summary

The target of rapamycin (TOR) pathway regulates protein translation in eukaryotes. This review details how TOR impacts translation by controlling key components and ribosome abundance in yeast and mammals.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The target of rapamycin (TOR) pathway is a crucial regulator of cell growth and metabolism.
  • Translation, the process of protein synthesis, is tightly controlled in eukaryotic cells.

Purpose of the Study:

  • To provide an overview of eukaryotic translation and its regulation.
  • To describe the role of the TOR pathway in modulating translation.

Main Methods:

  • Literature review of studies on TOR pathway and translation.
  • Analysis of mechanisms by which TOR affects translation components.

Main Results:

  • The TOR pathway influences translation through phosphorylation of key translation factors.
  • TOR signaling regulates the production of ribosomes and translation machinery.

Conclusions:

  • The TOR pathway is a central regulator of translation in both yeast and mammals.
  • Understanding TOR-mediated translation control offers insights into cellular processes and disease.

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