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Updated: Aug 2, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of some novel imidazolinones as potent anticonvulsant agents
Hashmukh Joshi1, Paresh Upadhyay, Denish Karia
1Department of Home Science, Saurashtra University, 5, Rajkot, India. hdjoshi1@rediffmail.com
Abstract:
Imidazolinone derivatives of IIa-IIc, IIIa-IIIf and IVa-IVf have been synthesised by the condensation of some known sulpha drugs with 5-oxazolone derivatives, which were prepared by Erlenmeyer condensation of benzoyl glycine with different aldehydes in the presence of sodium acetate and acetic anhydride. The constitution of the products has been supported by elemental analysis and IR, 1H-NMR spectral data. The products have been screened for their (a) in vitro growth inhibitory activity against several microorganisms and (b) in vivo anticonvulsant activity.
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