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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

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Alterations in plasma angiogenic growth factor concentrations after coronary artery bypass graft surgery:

Yves Denizot1, Laurence Guglielmi, Elisabeth Cornu

  • 1UMR CNRS 6101, Faculté de Médecine, 2 rue Dr. Marcland, 87025 Limoges, France. yves.denizot@unilim.fr

Cytokine
|October 17, 2003
PubMed

Insights

Cardiac surgery significantly alters angiogenic growth factor levels, with epidermal growth factor decreasing and transforming growth factor beta1 and basic fibroblast growth factor increasing. Post-operative complications correlate with specific growth factor elevations.

Area of Science:

  • Cardiovascular Surgery
  • Angiogenesis Research
  • Growth Factor Biology

Background:

  • Cardiac surgery, particularly with extracorporeal circulation (ECC), can profoundly impact systemic physiological processes.
  • Understanding the dynamics of angiogenic growth factors during and after cardiopulmonary bypass is crucial for managing patient recovery and potential complications.

Purpose of the Study:

  • To investigate alterations in plasma concentrations of key angiogenic growth factors – basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and transforming growth factor beta1 (TGFbeta1) – during and after coronary artery bypass graft (CABG) surgery.
  • To explore potential associations between post-operative complications and the systemic release of these angiogenic factors.

Main Methods:

  • Plasma levels of bFGF, VEGF, EGF, and TGFbeta1 were measured in 32 patients undergoing CABG with ECC.
  • Measurements were taken at various time points: during ECC, immediately after cross-clamp release, and at 6 and 24 hours post-operatively.

Main Results:

  • Epidermal growth factor (EGF) levels significantly decreased during ECC and remained low up to 24 hours post-operatively.
  • Transforming growth factor beta1 (TGFbeta1) and basic fibroblast growth factor (bFGF) concentrations increased significantly at the end of ECC and after cross-clamp release, returning to baseline by 6 hours post-operatively.
  • Vascular endothelial growth factor (VEGF) levels showed significant increases at 6 and 24 hours post-operatively.
  • Elevated bFGF levels post-cross-clamp release were noted in patients with respiratory impairments.
  • Higher plasma VEGF levels at 24 hours post-operatively were observed in patients with cardiovascular and hematological impairments.

Conclusions:

  • The angiogenic network is significantly altered during and after cardiopulmonary bypass.
  • Specific post-CABG complications, such as respiratory, cardiovascular, and hematological impairments, are associated with the systemic release patterns of bFGF and VEGF.

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