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Phenolic derivatives from Wigandia urens with weak activity against the chemokine receptor CCR5
Shugeng Cao1, Christine Rossant, Siewbee Ng
1MerLion Pharmaceuticals, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240.
Abstract:
Three compounds, 2,3-dihydroxy-4-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran (1), 8-methoxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-6-ol (2) and 4-methoxy-3-(3-methyl-2-butenyl)-benzoic acid (3), have been isolated from Wigandia urens. The structures of compounds 1, 2 and 3 were determined from spectroscopic data and showed activity in a CCR5 assay with IC(50) values of 33, 46 and 26 muM respectively.
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