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Related Experiment Video

Updated: May 5, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

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Receptor "cross talk" in innate immunity.

Eicke Latz1, Douglas T Golenbock

  • 1Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

The Journal of Clinical Investigation
|October 17, 2003
PubMed
Summary

Activated neutrophils upregulate Toll-like receptor 2 (TLR2) on endothelia through cell-cell interaction and NAD(P)H oxidase. This reveals a novel mechanism in the innate immune system's complexity.

Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Toll-like receptors (TLRs) are crucial for innate immunity, recognizing pathogen-associated molecular patterns.
  • TLR2 plays a significant role in immune responses to microbial stimuli.

Purpose of the Study:

  • To elucidate the mechanism by which TLR2 expression is regulated on endothelial cells.
  • To investigate the role of polymorphonuclear neutrophils in modulating endothelial TLR2 levels.

Main Methods:

  • The study utilized cell-cell interaction models involving endothelial cells and activated polymorphonuclear neutrophils.
  • NAD(P)H oxidase activity was assessed as a key component of the interaction.

Main Results:

  • Activated polymorphonuclear neutrophils were found to upregulate TLR2 expression on endothelial cells.

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  • This upregulation occurs via a novel mechanism involving direct cell-cell contact and NAD(P)H oxidase activity.

    • Conclusions:

    • A new pathway for innate immune regulation involving neutrophil-endothelial cell interaction has been identified.
    • The findings highlight the intricate complexity of the innate immune system and TLR2 function.