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Updated: Aug 30, 2026

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro
Published on: August 28, 2019
Excitatory effects of 5-hydroxytryptamine on the medial vestibular nuclear neuron via the 5-HT2 receptor
Han-Seong Jeong1, Young Chai Lim, Tae Sun Kim
1Department of Physiology, Chonnam National University Medical School, Gwaugju, Korea.
Abstract:
This study was designed to investigate the mechanisms of action of the 5-HT2 receptor on the spontaneous electrical activity and potassium currents of the rat medial vestibular nuclear neurons using whole-cell patch clamp recordings. The spike width of spontaneous action potential was not affected by 5-alpha-methylhydroxytryptamine. The spike frequency and resting membrane potential was increased by 5-alpha-methylhydroxytryptamine. The amplitude of afterhyperpolarization was decreased by 5-alpha-methylhydroxy-tryptamine. The peak current of the potassium currents of the neuron treated with 5-alpha-methylhydroxytryptamine was decreased. After blockade of calcium-dependent potassium currents, 5-alpha-methylhydroxytryptamine did not inhibit potassium currents. These results suggest 5-alpha-methylhydroxytryptamine increases spontaneous firing of the medial vestibular nuclear neurons by inhibiting calcium dependent potassium currents.
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