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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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Related Experiment Video

Updated: Jul 9, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Published on: February 3, 2016

Cyclic vomiting syndrome: a brain-gut disorder.

B U Li1, Larry Misiewicz

  • 1Department of Pediatrics, Feinberg School of Medicine, Northwestern University and Children's Memorial Hospital Chicago, IL 60614, USA. bli@childrensmemorial.org

Gastroenterology Clinics of North America
|October 18, 2003
PubMed
Summary

Cyclic Vomiting Syndrome (CVS) understanding has advanced, yet patients face numerous tests. Ongoing research into migraine mechanisms may yield new therapies for CVS.

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Area of Science:

  • Neurology
  • Gastroenterology
  • Genetics

Background:

  • Cyclic Vomiting Syndrome (CVS) is a distinct clinical entity.
  • Despite recognition, patients experience frequent hospitalizations and diagnostic procedures.
  • Controlled therapeutic studies are limited.

Purpose of the Study:

  • To summarize recent advancements in understanding Cyclic Vomiting Syndrome (CVS).
  • To highlight current empirical treatment approaches.
  • To discuss ongoing research directions for future therapies.

Main Methods:

  • Review of international interdisciplinary clinical and research efforts.
  • Analysis of empirical therapeutic strategies (anti-migraine, anti-emetic, anti-epileptic).
  • Overview of current investigations into migraine mechanisms.

Main Results:

  • Substantial advancement in understanding CVS over the last decade.
  • Development of reasonably effective empirical treatment regimens.
  • Identification of key research areas including NMR spectroscopy, mitochondrial DNA, and autonomic function.

Conclusions:

  • Despite progress, CVS management requires further research.
  • Ongoing investigations into cellular energetics and brainstem regulation show promise for future breakthroughs.
  • New therapies for CVS are anticipated in the coming decade.