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Unkei-to for correcting luteal phase defects
Takahisa Ushiroyama1, Atsushi Ikeda, Satoko Higashio
1Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp
The Journal of Reproductive Medicine
|October 18, 2003
Summary
Unkei-to effectively treats luteal phase defects by normalizing hormone levels and improving reproductive parameters. This herbal medicine significantly enhances fertility outcomes in women with luteal phase defects.
Area of Science:
- Reproductive Endocrinology
- Traditional Chinese Medicine
Background:
- Luteal phase defects (LPD) are a common cause of infertility.
- Current treatments for LPD have varying efficacy and side effect profiles.
Purpose of the Study:
- To evaluate the clinical effectiveness of Unkei-to in managing luteal phase defects.
- To investigate the hormonal and ultrasonographic changes associated with Unkei-to treatment.
Main Methods:
- A comparative study involving 103 women with LPD treated with Unkei-to and 94 control subjects.
- Hormonal assays (gonadotropins, estradiol, progesterone) and ultrasonography (follicle size, endometrial thickness) were performed.
- Basal body temperature was monitored to assess luteal phase length.
Main Results:
- Unkei-to treatment led to significant hormonal modulation, including decreased luteinizing hormone and increased 17 beta-estradiol and progesterone levels.
- Significant improvements in dominant follicle development and endometrial thickness were observed.
- A 43% prolongation of the luteal phase, a 79.6% correction rate of LPD, and a 49.5% pregnancy rate were achieved.
Conclusions:
- Unkei-to demonstrates potential in normalizing the hypothalamic-pituitary-ovarian axis and improving the luteal phase endocrine environment.
- The findings suggest Unkei-to is a promising therapeutic option for women with luteal phase defects.
- Further research is warranted to elucidate the precise mechanisms of action.