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Related Experiment Videos

Case report: sustained-release verapamil overdose causing stroke: an unusual complication.

A R Shah1, B R Passalacqua

  • 1Department of Cardiology, UNR Medical School, NV.

The American Journal of the Medical Sciences
|December 1, 1992
PubMed
Summary

A woman experienced severe complications, including a rare stroke, after ingesting sustained-release verapamil. This case highlights the critical need for awareness regarding slow-release medication overdoses.

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Area of Science:

  • Cardiology
  • Neurology
  • Clinical Pharmacology

Background:

  • Sustained-release verapamil overdose is a serious medical emergency.
  • Verapamil is a calcium channel blocker used to treat hypertension and arrhythmias.
  • Overdoses can lead to cardiovascular and metabolic disturbances.

Observation:

  • A 47-year-old woman ingested 7.2 gm of sustained-release verapamil.
  • She presented with hypotension, idioventricular rhythm, acidosis, and hyperglycemia.
  • The patient developed aspiration pneumonia requiring mechanical ventilation.

Findings:

  • The patient suffered a stroke due to left cerebral hemispheric damage, an unusual complication of verapamil overdose.
  • Stroke is rarely reported in verapamil toxicity literature.

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  • Management included antibiotics and mechanical ventilatory support.

    • Implications:

    • This case underscores the potential for severe and unusual complications from sustained-release verapamil overdose.
    • Healthcare providers must be vigilant for rare neurological events like stroke in verapamil toxicity.
    • Awareness of slow-release medication challenges is crucial for effective overdose management.