Related Experiment Video

Updated: Aug 30, 2026

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

Min Li-Weber1, Peter H Krammer

  • 1Tumor Immunology Program G0300, German Cancer Research Center (DKFZ), INF 280, D-69120 Heidelberg, Germany. m.li-weber@dkfz-heidelberg.de

Seminars in Immunology
|October 18, 2003
PubMed

Insights

The CD95/CD95L system regulates immune homeostasis and tolerance. Understanding its molecular mechanisms and transcription factors is key to developing therapies for related diseases.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • The CD95/CD95L pathway is crucial for immune homeostasis and peripheral tolerance.
  • Dysregulation of this system is linked to severe diseases.

Purpose of the Study:

  • To review the role of the CD95/CD95L system in immunity.
  • To focus on the signals and transcription factors regulating CD95L expression.

Main Methods:

  • Literature review of CD95/CD95L system functions.
  • Analysis of transcription factors (NF-AT, Egr, NF-kappaB, AP-1, c-Myc, Nur77, IRFs, SP-1, ALG-4, ROR(gamma)t, CIITA) involved in CD95L expression.

Main Results:

  • The CD95/CD95L system plays a vital role in terminating immune responses.
  • Identified multiple transcription factors that regulate CD95L expression.

Conclusions:

  • A deep understanding of CD95L molecular mechanisms can guide therapeutic strategies.
  • Targeting the CD95/CD95L pathway offers potential for treating related diseases.

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