Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MicroRNAs and cancer.

Michael T McManus1

  • 1Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA. mmcmanus@mit.edu

Seminars in Cancer Biology
|October 18, 2003
PubMed
Summary

MicroRNAs, a class of noncoding RNAs, are implicated in cancer development. This review explores their potential role in oncogenesis, challenging traditional views of cancer gene mutations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiplexed perturbation enables scalable pooled screens.

Nature methods·2026
Same author

CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death.

Science advances·2025
Same author

Scalable imaging-based profiling of CRISPR perturbations with protein barcodes.

bioRxiv : the preprint server for biology·2025
Same author

RainBar: Optical Barcoding for Pooled Live-Cell Imaging with Single-Cell Resolution.

bioRxiv : the preprint server for biology·2025
Same author

Decoding gene regulation with CRISPR perturbations.

Nature biotechnology·2024
Same author

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.

Nature communications·2024

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Cancer is characterized by loss of cell identity and uncontrolled proliferation.
  • Traditionally, oncogenesis is linked to mutations in protein-encoding genes (oncogenes and tumor suppressors).
  • Noncoding RNAs (ncRNAs) are emerging as critical regulators of cellular processes.

Purpose of the Study:

  • To propose a role for microRNAs in the process of oncogenesis.
  • To highlight the potential shift in understanding cancer development beyond protein-coding genes.
  • To review current data suggesting microRNA involvement in human diseases.

Main Methods:

  • Literature review of recent studies on noncoding RNAs and cancer.
  • Analysis of data linking microRNAs to cellular homeostasis and development.
  • Synthesis of evidence supporting microRNA function in oncogenesis.

Main Results:

  • Noncoding RNAs, particularly microRNAs, play significant roles in biological regulation.
  • Emerging evidence points to microRNAs as key players in human diseases, including cancer.
  • MicroRNAs offer a new perspective on the molecular mechanisms underlying oncogenesis.

Conclusions:

  • MicroRNAs represent a novel class of molecules involved in cancer development.
  • The role of microRNAs in oncogenesis warrants further investigation.
  • Understanding microRNA functions could lead to new diagnostic and therapeutic strategies for cancer.

Related Experiment Videos