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Pediatric invasive pneumococcal disease in a teaching hospital in Bangkok

Sayomporn Sirinavin1, Malai Vorachit, Ammarin Thakkinstian

  • 1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|October 18, 2003
PubMed

Insights

Drug-resistant Streptococcus pneumoniae infections are increasing in children in Asia. Invasive pneumococcal disease is more common in dry months and linked to underlying conditions, with higher fatality rates.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Epidemiology

Background:

  • Rising prevalence of drug-resistant Streptococcus pneumoniae (SP).
  • Limited data on invasive pneumococcal disease (IPD) in Asian children.
  • Need for understanding SP epidemiology and clinical features in pediatric populations.

Purpose of the Study:

  • To investigate the epidemiology and clinical characteristics of invasive pneumococcal disease in children.
  • To assess the trends of penicillin-non-susceptible SP (PNSSP) infections.
  • To identify risk factors for PNSSP infection and associated mortality.

Main Methods:

  • Retrospective review of medical records of pediatric patients (0-15 years).
  • Data collected from a teaching hospital in Bangkok between 1971 and 2000.
  • Analysis of infection types, patient demographics, underlying conditions, and outcomes.

Main Results:

  • Penicillin-non-susceptible SP (PNSSP) strains became predominant by 1996-2000 (71%).
  • Most patients (74%) were under 60 months old, and 66% had underlying conditions.
  • Common infections included bacteremia, pneumonia, and meningitis; case-fatality rates were higher in those with underlying conditions (18% vs 2%).
  • Infections peaked during dry months (November-April).

Conclusions:

  • The study population had a high rate of underlying conditions and PNSSP infections.
  • Invasive pneumococcal disease incidence was notably higher during dry seasons.
  • Low proportion of bacteremia without focus observed.
Abstract

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