[Glutathione-S-transferase activity in various brain regions of normal and fasting animals]

Glutathione-S-transferase Y alpha Y alpha (GT-Y alpha Y alpha) and YbYb (GT-YbYb) activities were studied in cytosolic fraction of the cortical (limbic, orbital and sensorimotor cortex) and subcortical (myelencephalon, mesencephalon, hypothalamus) structures of rat brain under different terms of starvation (1, 2, 3, 5 and 7 days). In all brain structures GT-YbYb activities were approximately 2 times higher than those of the GT-Y alpha Y alpha activities. Basal activity of both forms of glutathione-S-transferase in cortical structures was also 2 times higher than that in the stem structures. Significant increase of activities of the GT-Y alpha Y alpha and GT-YbYb was selected both in cortical and subcortical structures on the third day and especially on the fifth day of starvation. It was concluded, different rat brain structures possess high glutathione-S-transferase activities, which are activated after long term starvation.