Related Experiment Videos
Epidermal growth factor-like activity in mares' milk
M J Murray1, R P Schaudies, D M Cavey
1Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Lessburg 22075.
American Journal of Veterinary Research
|October 1, 1992
Summary
Epidermal growth factor (EGF)-like activity is highest in mares' presuckle colostrum. EGF levels decrease after suckling and remain stable throughout early lactation.
Area of Science:
- Veterinary Medicine
- Animal Science
- Biochemistry
Background:
- Colostrum and milk contain bioactive factors crucial for neonatal development.
- Epidermal growth factor (EGF) plays a vital role in cellular growth and differentiation.
Purpose of the Study:
- To quantify Epidermal growth factor (EGF)-like activity in mares' colostrum and milk.
- To determine the changes in EGF-like activity during early lactation in mares.
Main Methods:
- Radioreceptor assay was used to measure EGF-like activity.
- Milk samples were collected from 22 mares at various time points: presuckle, postsuckle, and days 1, 2, 4, and 8 of lactation.
Main Results:
- Presuckle colostrum exhibited the highest mean EGF-like activity (17.8 ng/ml).
- EGF-like activity significantly decreased after suckling (postsuckle, 9.7 ng/ml).
- Activity remained relatively stable and lower from day 1 through day 8 of lactation.
Conclusions:
- Mares' colostrum, particularly before suckling, is a rich source of EGF-like activity.
- EGF-like activity in mare's milk declines post-suckling and during early lactation.