Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oligonucleotides and derivatives as gene-specific control agents.

Jian-Sheng Sun1, Claude Hélène

  • 1Laboratoire de Biophysique, USM0503 Régulation et Dynamique des Génomes, Muséum National d'Histoire Naturelle, UMR8646 CNRS-MNHN, U565 INSERM, Paris, France. sun@mnhn.fr

Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
PubMed
Summary

Advancements in functional genomics and genome sequencing enable the creation of gene-specific reagents. This review focuses on oligonucleotide-based chemical genomics for targeted cellular and in vivo applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinspire-Explore: Taxonomy-Driven Exploration of Biodiversity Data for Bioinspired Innovation.

Biomimetics (Basel, Switzerland)·2024
Same author

Revisiting Nature's "Unifying Patterns": A Biological Appraisal.

Biomimetics (Basel, Switzerland)·2023
Same author

Combining DNA Barcoding and Chemical fingerprints to authenticate Lavender raw material.

International journal of cosmetic science·2021
Same author

The Clinical Significance of Changes in Serum New Cytokine CYTL1 in Patients with Knee Osteoarthritis.

International journal of general medicine·2021
Same author

Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis.

Human molecular genetics·2021
Same author

Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors.

Frontiers in oncology·2019

Area of Science:

  • Genomics
  • Chemical Biology
  • Molecular Biology

Background:

  • Genome sequencing projects provide foundational knowledge for functional genomics.
  • Functional genomics enables the use of gene-specific reagents for research and therapeutics.
  • Chemical genomics aims to develop molecules targeting specific genes or gene products.

Purpose of the Study:

  • To review the progress in oligonucleotide-based approaches within chemical genomics.
  • To discuss other nucleic acid-based and SELEX-based strategies.
  • To explore DNA-specific ligands for gene targeting.

Main Methods:

  • Focus on oligonucleotide-based chemical genomics.
  • Discussion of nucleic acid-based approaches.
  • Inclusion of SELEX (Systematic Evolution of Ligands by Exponential Enrichment) methods.

Related Experiment Videos

  • Exploration of DNA-specific ligands.

    • Main Results:

    • Oligonucleotide-based methods are advancing chemical genomics.
    • Diverse nucleic acid and SELEX approaches offer gene-targeting capabilities.
    • Development of sequence-specific DNA-binding molecules is progressing.

    Conclusions:

    • Oligonucleotide-based strategies are key to advancing chemical genomics.
    • A range of molecular tools are being developed for precise gene manipulation.
    • These advancements hold promise for both basic research and therapeutic development.