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Related Experiment Videos

A role for oligonucleotide-based RNA-knock down technologies in functional genomics.

Gabriele Dorn1, Jonathan Hall, Dieter Hüsken

  • 1Functional Genomics, Novartis Pharma AG, Basel, Switzerland.

Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
PubMed
Summary

Functional genomics generates numerous gene targets for drug discovery. Oligonucleotide-based RNA knock-down technologies help filter and prioritize these candidates for pharmaceutical development.

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Area of Science:

  • Genomics and Bioinformatics
  • Drug Discovery and Development

Background:

  • Functional genomics studies yield extensive gene target data for the pharmaceutical industry.
  • Sources include gene expression profiling (DNA microarrays, proteomics) and database mining.

Purpose of the Study:

  • To explore the utility of RNA knock-down technologies in filtering gene targets.
  • To assess the role of these technologies in prioritizing candidates for drug discovery.

Main Methods:

  • Utilizing oligonucleotide-based RNA knock-down techniques.
  • Applying antisense and RNA interference (RNAi) strategies.

Main Results:

  • Demonstrated effectiveness of RNA knock-down in candidate filtering.
  • Showcased prioritization capabilities for drug discovery targets.

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Conclusions:

  • RNA knock-down technologies are valuable tools for pharmaceutical research.
  • These methods enhance the efficiency of identifying viable drug targets.