5'-O-ester prodrugs of potent and selective anti-HIV agent--2',3'-dideoxy-3'-fluoro-2-thiothymidine (S2FLT):
A Miazga1, N E Poopeiko, A Piasek
1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland. jagoda@poczta.ibb.waw.pl
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
Novel synthesis of 2',3'-dideoxy-3'-fluoro-2-thiothymidine (SFLT) based on transformation of appropriately protected 1-beta-D-threo-ribofuranosylthymine is presented. The synthesis and evaluation of SFLT 5'-O-ester prodrugs enzymatic hydrolysis, as well as their anti-HIV activity, is also described.
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