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Updated: Aug 12, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Investigations of nucleoside H-phosphonamidate in the design of nucleotide prodrug
D Egron1, J L Imbach, G Gosselin
1Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
Abstract:
The synthesis, anti-HIV activity and stability studies of a H-phosphonamidate derivative of 3'-azido-2',3'-dideoxythymidine (AZT) incorporating a N,N-diisopropylamino residue as first model of alkylamino group are reported. The results demonstrate that such phosphorylated structure exerts its biological effects via chemical hydrolysis into the corresponding H-phosphonate, precursor of the parent nucleoside.
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