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Urinary modified nucleosides as tumor markers
E Dudley1, F Lemiere, W Van Dongen
1Biochemistry Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.